The reports say least three people are reported injured.
It is unclear how many may be trapped.
Firefighters are working from outside the building itself due to its lack of structural integrity.
A injured man is led to an ambulance by an FDNY first responder after a parking garage collapsed Tuesday in Lower Manhattan.Getty Images
Mayor Eric Adams called the building completely unstable.
The chief of the NYFD said 6 people, whom he called workers, were injured.
Four of those people were taken to the hospital, one refused medical treatment and another died.
Members of the Fire Department of New York arrive at the scene of a parking garage that collapsed in lower Manhattan on TuesdayGetty Images
The chief said NYFD was using drones, including a robotic dog, to search the building.
One person was removed from the upper floors, per NYFD.
It is believed that everyone who may have been trapped inside the structure made it out.
A city official said there had been multiple building violations related to the structure, but none were outstanding.
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The collapse was also reported on Notify NYC, the citysofficial emergency notification system.
Building Collapse: Expect traffic delays & emergency personnel in area of Ann Street & Nassau Street, Manhattan.
Multilingual & ASL Link:https://t.co/WgzTrHFgUi.
Some of the injured were taken to New York Presbyterian Hospital, which is about two blocks away.
NBC News says the second floor of the five-story parking garage collapsed into the first floor.
Images from the scene seem to indicate cars fell through the top level to those below.
The data pipe also reported that nearby Pace University has been evacuated.
