He never forgot a birthday and shared his genuine delight for silliness with everyone he met.

My family and I will miss him.

Said Danny DeVito: Really loved working with him.

Paul Reubens in Pee-wee’s Big Adventure

Paul Reubens in 1985’s ‘Pee-wee’s Big Adventure’Everett

Colleagues and friends sharing their tributes on Reubens Instagram page include:

Marisa Tomei: No no no .

Oh heart break

Judd Apatow: This is devastating news.

He made the world so happy!

Tim Burton remembers Paul Reubens

The Groundlings paid tribute to Reubens in a statement: “We were deeply saddened to hear of Paul Reubens passing today. As an iconic member of The Groundlings in the 1970-80s, Paul created his infamous character of Peewee Herman here, which became a cultural phenomenon that spanned decades. Paul’s contributions to comedy and entertainment have left a lasting impact on the world, and he will be greatly missed by all in the Groundlings community. We love you, Paul.”

Some of the biggest laughs I have every experienced was watching him perform live.

Sara Gilbert: Paul you were the kindest and most generous of spirit.

i will never have another birthday without thinking of the pictures and videos you would send all day.

you always made me feel so loved and special.

i hope to be half the friend you were.

love you forever, peewee.

Clint Howard: Oh my.

Keep the angels laughing.

Will Sasso: We love you forever, Mr. Reubens.

Ricki Lake: I. Paul was my friend for decades.

I cant believe it.

Almost nothing was more enjoyable than a meal with Paul.

Rest in peace, my sweet friend.

Camryn Manheim: My heart just fell into a million pieces.

I love you Paul.

I have saved everyone of your Christmas cards and birthday wishes.

You are a kind and gentle soul and Ive always loved being in your orbit.

Rest in peace my friend.

Sandra Bernhard: A true genius glad I got to work with him so sad.

Jason Hervey: Love you Paul….This hurts.

Adam Goldberg: I met him barely and briefly a few times and he was so lovely.

He never forgot a birthday and shared his genuine delight for silliness with everyone he met.

My family and I will miss him.

No tweet can capture the magic, generosity, artistry, and devout silliness of Paul Reubens.

Everyone I know received countless nonsensical memes from Paul on their birthday, and I mean EVERYONE.

His surreal comedy and unrelenting kindness were a gift to us all.

Damn, this hurts.

A post shared by Paul Feig (@paulfeig)

One of the greatest comedies ever made.

RIP, Paul Reubens.

Thanks for the laughter.pic.twitter.com/knoSUDhR16

One of my favorite movie scenes of all time.

He made me laugh so hard and so often.Rest In Peace, Paul Reubens.https://t.co/Pw2lNEmaDv

Rip Paul Reubens.

You always made me laugh.pic.twitter.com/BNoXcClSZG

Paul Reubens has passed away.

He was one of my favorites.

LOVED his mind, his movies, his performances.

An original, and a genius.

May he Rest in Peace.pic.twitter.com/ycI0WO3aqJ

Aw man… Pee-wee Herman has ridden off to heaven.

Thank you for giving us Pee-wee.

He said it was so weird and so great at the same time.

It was odd and it was fantastic.

We are devastated David was one of his closest friends.

And he always showed up for us.

He was a beautiful human being, Arquette commented under the post.

No one ever like him ever, Andy Cohen commented.

Really gonna miss him,Walking Deadactor Norman Reedus commented under the post.

A post shared by emily hampshire (@emilyhampshire)

Gutted.

One in all time.

#PaulReubens#PeeWeeHermanpic.twitter.com/GMcBaEgWix

Reubens also was known for his compassion for animals.